OMEGA Engineering is your source for process measurement and control. Everything from thermocouples to chart recorders and beyond. Temperature, flow and level. Precision Calibration Equipment and Ice Point Reference. The National Center Research Resources (NCRR). NCRR SHARED INSTRUMENTATION GRANT. 2000 PURPOSE The National Center for Research Resources (NCRR). Each applicant institution must propose a Principal Investigator who can assume administrative/scientific. Because the cost of new construction and renovation is high, NCRR could look to commercial producers to supplement institutional colonies. Commercial breeders could be brought in as partners to investigators and institutions to help meet needs for maintenance and solving problems. Outsourcing mechanisms—such as contracts between research institutions and commercial breeders to provide and distribute animals of the required genotypes, phenotypes, and health quality—could be developed and used to relieve the intense pressure on research resources and institutions. For supply of some wild- derived organisms, centers for acquisition and supply of animals are needed, rather than breeding colonies of genetically defined animals. Techniques for careful and injury- free acquisition and transport of wild animals to the laboratory have yet to be developed for many species, particularly aquatic ones. A great need has been identified for the preservation of many different laboratory animal species. Research is needed to make cryopreservation and recovery more reliable, cheaper, and applicable to a broader range of species. For example, it costs thousands of dollars to cryopreserve a single mouse line and thousands more to recover it from the frozen state because of the uncertain outcome and the often- necessary repeated attempts. Support to make common the practical use of cryopreservation of ovaries, ova, sperm, and intracytoplasmic sperm injection would probably facilitate the use of this technology for a wide variety of animal species. DEVELOPMENT OFGENETICMAPS FORADDITIONALMODELSPECIESThere is a critical role for NCRR in furthering functional genomics studies in outbred models, particularly primates and some aquatic organisms. Such species are outside the mission of the Human Genome Project.
For example, nonhuman primates, dogs, and cats develop many of the same complex diseases that afflict human beings, but genetic maps for these species are woefully inadequate. Mutagenesis programs using zebrafish are likely to play a major role in increasing the understanding of gene function. The genetic map of the zebrafish is in progress, with NCRR funding, but needs to be improved. Results of 4. 0 years of neurobiologic and behavioral research exist for Aplysia, and it continues to be used in research on neurobiology and behavior; but virtually nothing is known about its genetics. Identification of biomedically relevant phenotypes is driven by the disease or metabolic process in question and thus is unlikely to be a primary responsibility of NCRR. Not so obvious, however, are identifying appropriate models for disease- related phenotypes and finding the genes that underlie the phenotypes. There is an important role for NCRR in both. Identifying appropriate models for disease- related phenotypes is a fundamentally a database problem, in which information on the physiology, pathology, metabolism, and so on, of a wide variety of species should be made available to those engaged in research on common diseases. Likewise, experimental information that refines the characterization of model organisms should be continually incorporated into a database (curation). Because of its personnel's broad experience with laboratory animals, NCRR is the obvious sponsor for the building and maintenance of such a database.
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